Lafutidine 2-[(2-furylmethyl) sulfinyl]-N-((2Z)-4-{[4- (piperidin-1- ylmethyl) pyridin-2-yl] oxy} but-2-en-1- yl) acetamide are used in the treatment of anti ulcer. Antisecretory drugs are used in the treatment and prophylaxis of peptic ulcer disease some are also employed in other disorders associated with gastric hyperacidity such as gastro-oesophageal reflux disease and dyspepsia. Few analytical methods like liquid chromatography, stability indicating HPLC and biological assay are reported, there was no mention of a method based on spectrophotometric estimation. The proposed UV- Visible spectrophotometric method is a simple, specific, rapid, accurate and economic for quantitative estimation of lafutidine. The solvent used was methanol for parent dilution and then sodium hydroxide for further dilution. Aabsorption minima in first order derivative spectra was found 284 nm and area under curve was measured from 275-295nm, the drug followed a linear relationship in the range of 10-35μg/ml while the correlation coefficient was at 0.999. The recovery was 99.89% (+0.50) and the coefficient of variance for intraday and inter day was found to be less than 5%, LOD and LOQ for this method was found 10 μg/ml and 35 μg/ml respectively. This method is found suitable for day to day analysis of lafutidine in bulk and its formulation.
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